Another scorching deployment of common sense from jwz (also, the simplest instructions you will ever see for scheduling daily backups - until Time Machine.)

Me = SuperDuper! daily. No offsite backup though.

I actually have very little irreplaceable stuff on my home 'puter. My email is stored on a bunch of disks in a Google server farm. My music is on three disks, counting backup and iPod. Most of my favorite photos are on Flickr. Etc.